Window to sleep, aisle to move, exit row for legroom (if you're able-bodied and don't need under-seat storage), front of the cabin to deplane fast. Avoid the last row, seats by lavatories and galleys, and 'misaligned' windows — check a seat map first.
Sleepers: window, mid-cabin, away from galleys and lavatories.
Movers and tall people: aisle, or an exit row (extra legroom; you must be willing to assist in an emergency; no bags at your feet). Bulkhead seats have legroom but fixed armrests and bassinet positions.
Nervous flyers: over the wing — the smoothest ride.
Fast exit: the front, but the last rows board first on some airlines.
Avoid: the last row (may not recline), seats next to lavatories (traffic, smell), ‘window’ seats with no window (common on certain rows), and middle seats in 3-4-3 economy on long-haul.
Use AeroLOPA for accurate layouts and check whether your airline charges for seat selection — it’s often free at online check-in.
Related questions
How do I sleep on a plane in economy?
Pick a window seat away from galleys and lavatories, board rested not exhausted, use a neck pillow that supports the chin, an eye mask and earplugs, skip alcohol and heavy meals, and sleep on the destination's schedule. Full answer →
How do I survive a long-haul flight?
Choose your seat deliberately, dress in layers, drink water and skip alcohol, walk every two hours, download entertainment in advance, bring your own snacks, and plan sleep around the destination's clock. Compression socks help on flights over eight hours. Full answer →
Airline, airport and government rules change without notice. Treat this as a starting point and confirm with the airline or authority for your specific trip. Request a correction if something is out of date.